Rtw Investments
Rtw Investments reported 84 stocks worth $11.7B in its 13F filing for Q2 2026, filed Aug 14, 2026. Its largest holdings are MDGL (9.1%), ARGX (5.6%) and PTCT (5.4%). Compared with Q1 2026, the fund opened new positions in KLRA, GPCR and AXGN, added to CGON, TNGX and SYRE, trimmed NTRA, TSHA and COGT and sold out of ISRG, WAY and ARWR.
Holdings
| # | Stock | Value | Weight | Shares | Change | Shares, 8 qtrs | Held |
|---|---|---|---|---|---|---|---|
| 1 |  MDGL Madrigal Pharmaceuticals Inc | $1.1B | 9.1% | 2M | No change | 8 of 8 | |
| 2 |  ARGX Argenx SE | $658M | 5.6% | 709K | No change | 8 of 8 | |
| 3 |  PTCT Ptc Therapeutics Inc | $632M | 5.4% | 7.7M | No change | 8 of 8 | |
| 4 |  PTGX Protagonist Therapeutics Inc | $620M | 5.3% | 5.1M | No change | 8 of 8 | |
| 5 |  CGON CG Oncology Inc | $605M | 5.2% | 8.5M | +1.5M (+22%) | 8 of 8 | |
| 6 |  INSM Insmed Inc | $516M | 4.4% | 4.8M | No change | 8 of 8 | |
| 7 |  TNGX Tango Therapeutics Inc | $435M | 3.7% | 13.9M | +600K (+5%) | 3 of 8 | |
| 8 |  SYRE Spyre Therapeutics Inc | $377M | 3.2% | 4.3M | +80K (+2%) | 8 of 8 | |
| 9 |  CELC Celcuity Inc | $346M | 3.0% | 3.3M | +265K (+9%) | 3 of 8 | |
| 10 |  ERAS Erasca Inc | $329M | 2.8% | 17.9M | +1.8M (+11%) | 3 of 8 |
Positions at Jun 30, 2026, as reported. Change is against the fund's Q1 2026 filing; weight is the share of the fund's reported stocks.
Sold out
held in Q1 2026, gone in Q2 2026| Stock | Value last quarter | Shares sold |
|---|---|---|
APOGEE THERAPEUTICS INC | $234M | 2.8M |
APELLIS PHARMACEUTICALS INC | $148M | 3.7M |
 ISRG Intuitive Surgical Inc | $101M | 220K |
CENTESSA PHARMACEUTICALS PLC | $81.6M | 2.1M |
CRINETICS PHARMACEUTICALS IN | $52.7M | 1.5M |
🔒 Free account: see all 13.
Reported value
last 8 quartersThe value of the US stocks the fund reported, at quarter end prices. It moves with the market as well as with buying and selling.
Filings for Q2 2026
straight from the SEC| Filed | Form | Quarter | |
|---|---|---|---|
| Aug 14, 2026 | 13F-HR | Q2 2026 | SEC filing ↗ |
Other superinvestors
All hedge fund holdings →Rtw Investments 13F FAQ
What does Rtw Investments own?
Rtw Investments reported 84 stocks worth $11.7B in its 13F filing for Q2 2026, filed Aug 14, 2026. Its largest holdings are MDGL (9.1%), ARGX (5.6%) and PTCT (5.4%). The table above lists every position in the filing (the top 10 without an account).
What did Rtw Investments buy and sell in Q2 2026?
Compared with Q1 2026: 9 new positions, 25 added to, 8 trimmed and 13 sold out. New positions include KLRA, GPCR and AXGN. It sold all of ISRG, WAY and ARWR.
When will Rtw Investments file its next 13F?
Holdings as of Sep 30, 2026 are due by Nov 16, 2026. The filing appears on this page within minutes of reaching the SEC.
How much is Rtw Investments's portfolio worth?
The Q2 2026 filing reports $11.7B in US stocks. That leaves out cash, bonds, short positions and most foreign holdings, so the fund's total assets are usually larger.
For informational and educational purposes only. Not investment advice, and not a recommendation to buy or sell any security. Holdings come from the fund's SEC Form 13F filings as reported and show positions at the end of the quarter, up to 45 days before the filing. The fund may have changed its positions since. A 13F leaves out short positions, cash, bonds and most foreign holdings. See all hedge fund holdings.