SEPN Institutional Ownership
Who owns Septerna, Inc. and what the big funds did with it last quarter, from every SEC 13F filing. 156 funds reported holding SEPN at Jun 30, 2026, together owning 101.6% of the company.
- ▲95 buying vs 48 selling
- ▲Held by funds +3.3 pts
- ▲Funds holding +30
- ▲Superinvestors: 2 added, 1 cut
- ●Put/call not meaningful
What the filings show, not a forecast. Positions can be up to 45 days old and leave out short sales.
Funds holding and ownership
7 quartersQuarter over quarter
all 13F filers| Q2 2026 | This quarter | Q1 2026 | Change |
|---|---|---|---|
| Funds holding | 156 | 126 | +23.8% |
| In funds' top 10 | 4 | 4 | 0.0% |
| 13F shares | 47.4M | 45.9M | +3.3% |
| Held by funds | 101.6% | 98.4% | +3.3 pts |
| New positions | 46 | 22 | +109.1% |
| Increased | 49 | 43 | +14.0% |
| Reduced | 32 | 30 | +6.7% |
| Sold out | 16 | 24 | −33.3% |
| Calls (shares) | 640K | 0 | – |
| Puts (shares) | 360K | 0 | – |
| Put/call ratio | 0.56 | – | – |
Buyers vs sellers
adding or new vs cutting or sold outSuperinvestors in SEPN
All superinvestors →
Who owns SEPN
share of fund held shares- Index and passive funds11.4%
- Active managers and hedge funds80.7%
- Banks and brokers7.7%
- Pensions, insurers and other0.2%
The top 10 holders own 72.8% of all SEPN shares that funds reported. Groups are our own grouping of filers by name.
Filed so far for Q3 2026
18 funds changed their position- Profund Advisors LLCNew+38K sh
- State of WyomingTrimmed−12K sh
- Strs OhioAdded+6,200 sh
- VIRGINIA RETIREMENT SYSTEMS ET AlAdded+3,300 sh
- China Universal Asset Management Co., Ltd.Added+1,343 sh
🔒 Free account: see all 18.
Top holders
Q2 2026| # | Fund | Of company | Shares | Value | Change |
|---|---|---|---|---|---|
| 1 | RA Capital Management, L.P. | 14.99% | 7M | $234M | 0 |
| 2 | Trv GP V, LLC | 13.32% | 6.2M | $208M | 0 |
| 3 | Driehaus Capital Management LLC | 9.50% | 4.4M | $148M | +37K |
| 4 | Trv GP Vi, LLC | 9.02% | 4.2M | $141M | 0 |
| 5 | Samsara Biocapital, LLC | 6.75% | 3.1M | $105M | 0 |
| 6 | Goldman Sachs Group Inc | 6.56% | 3.1M | $103M | +156K |
| 7 | BlackRock, Inc. | 4.14% | 1.9M | $64.7M | +110K |
| 8 | Siren, L.L.C. | 4.07% | 1.9M | $63.6M | −100K |
| 9 | Avoro Capital Advisors LLC | 2.87% | 1.3M | $44.8M | 0 |
| 10 | Jupiter Topco LLC | 2.80% | 1.3M | $43.7M | – |
- Loomis Sayles & Co L P+625K sh+$20.9M
- Algert Global LLC+376K sh+$12.6M
- Catalio Capital Management, LP+242K sh+$8.1M
- First Light Asset Management, LLC+230K sh+$7.7M
- Longaeva Partners L.P.+224K sh+$7.5M
- Woodline Partners LP+186K sh+$6.2M
- Goldman Sachs Group Inc+156K sh+$5.2M
- Two Sigma Investments, LP+146K sh+$4.9M
- Bvf Inc/il−1.4M sh−$32.5M
- Venrock Adviser, LLC−506K sh−$12.2M
- ADAR1 Capital Management, LLC−149K sh−$5M
- Siren, L.L.C.−100K sh−$3.3M
- Millennium Management LLC−74K sh−$2.5M
- Checkpoint Capital L.P.−100K sh−$2.4M
- Invesco Ltd.−59K sh−$2M
- Hussman Strategic Advisors, Inc.−42K sh−$1.4M
SEPN institutional ownership FAQ
Who owns the most SEPN stock?
In Q2 2026 13F filings the largest holder of SEPN was RA Capital Management, L.P., followed by Trv GP V, LLC and Driehaus Capital Management LLC. Index fund managers are usually the biggest holders of large companies.
What percentage of SEPN is owned by institutions?
Funds that file 13F reports held 101.6% of SEPN's shares at Jun 30, 2026, compared with 98.4% a quarter earlier. That counts every manager with more than $100 million in US stocks.
Are hedge funds buying SEPN?
In Q2 2026, 95 funds bought SEPN (46 of them new positions) and 48 sold (16 sold out completely). Among well known investors, 2 added and 1 cut. Our fund sentiment for SEPN is strongly bullish.
What is SEPN's institutional put/call ratio?
Funds reported $12.1M of SEPN puts against $21.4M of calls, a put/call ratio of 0.56. Market makers and bank trading desks are left out, since their options are mostly hedges.
How current is this SEPN ownership data?
13F filings show holdings at the end of each quarter and are due within 45 days, so positions can be up to six weeks old when they appear. We add each new filing within minutes, and the "filed so far" list shows funds that have already reported the next quarter.
For informational and educational purposes only. Not investment advice, and not a recommendation to buy or sell any security. Fund sentiment summarises what 13F filings show and is not a forecast. Holdings come from SEC Form 13F filings as reported and show positions at the end of the quarter, up to 45 days before the filing. A 13F leaves out short positions, cash, bonds and most foreign holdings. See all hedge fund holdings.